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  • Title: Human platelet aggregation tests in vitro. Effects of dilazep.
    Author: Ponari O, Manotti C.
    Journal: Arzneimittelforschung; 1981; 31(1):97-101. PubMed ID: 7194099.
    Abstract:
    The effect of 1,4-bis-[3(3,4,,5-trimethoxybenzoyl-oxy)-propyl]-perhydro-1,4-diazepine (dilazep, Cormelian), a coronaroactive drug, was studied by various tests of hemostasis in vitro on human plasma. The antiplatelet action of the drug was clearly demonstrated: it inhibited, in appropriate concentrations, ADP, adrenaline and collagen induced aggregation platelet factor 3 (PF3) availability and clot retraction induced by ADP-reptilase. Conversely, coagulation tests as well as the lysis time of diluted whole blood were unaffected by the drug.
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