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  • Title: Therapy of advanced squamous carcinoma of the lung: cyclophosphamide vesus "COMB".
    Author: Bodey GP, Lagakos SW, Gutierrez AC, Wilson HE, Selawry OS.
    Journal: Cancer; 1977 Mar; 39(3):1026-31. PubMed ID: 71943.
    Abstract:
    The four-drug combination of cyclophosphamide, vincristine, methyl CCNU and bleomycin was compared to CTX alone in a prospective randomized trial. Only one of 20 patients treated with COMB and one of 27 patients treated with CTX achieved a partial response. CTX was associated with a significantly better survival than COMB among patients who were ambulatory at onset of therapy. Survival among non-ambulatory patients was similar with both regimens.
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