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  • Title: [Reabsorption of standardised intramuscular haematomas in rabbits treated with streptokinase per os (author's transl)].
    Author: Hettich R, Schunack G.
    Journal: Arzneimittelforschung; 1981; 31(2):306-8. PubMed ID: 7194647.
    Abstract:
    Standardised i.m. haematomas in rabbits were studied with and without oral administration of Varidase (containing streptokinase and streptodornase). 125I-fibrinogen was mixed with 2 ml of rabbit blood and reinjected i.m. The standardised haematomas were reabsorbed after 12 to 14 days. During the 3-day administration period of streptokinase the counts measured over the haematoma were even higher than in control animals. As during the therapy a high fibrinolytic activity was found, additional spontaneous bleeding into the haematomas may be suspected. When oral administration of streptokinase was stopped the decrease of counts detected in those animals was significantly accelerated as compared to non-treated animals. This indicates an accelerated reabsorption of those haematomas treated with streptokinase in a low concentration. These results were confirmed by microscopic findings.
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