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  • Title: Behavioral supersensitivity to methamphetamine following chronic treatment with (--)-sulpiride in the rat.
    Author: Montanaro N, Dall'Olio R, Gandolfi O, Vaccheri A.
    Journal: Boll Soc Ital Biol Sper; 1981 Feb 28; 57(4):401-6. PubMed ID: 7195265.
    Abstract:
    Hyperactivity induced by methamphetamine (4 mg/kg i.p.) was actographically evaluated in rats chronically treated with sulpiride stereoisomers and haloperidol. The trial was repeated with half dose of the stimulant after 8 days of neuroleptic withdrawal. (--)-Sulpiride and haloperidol antagonized the response to the full dose of methamphetamine and induced behavioral supersensitivity to the challenging dose. (+)-Sulpiride strongly enhanced the effect of 4 mg/kg of methamphetamine, but no relevant changes in dopaminergic sensitivity followed.
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