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  • Title: [7 alpha-Hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in normal and hyperplastic human prostate].
    Author: Morfin R, Floch H.
    Journal: C R Acad Hebd Seances Acad Sci D; 1977 Oct 10; 285(8):887-900. PubMed ID: 71958.
    Abstract:
    Incubation of 4-14C-5 alpha-androstane-3 beta, 17 beta-diol with human normal and hyperplastic prostate minces led to the NADPH-dependent production of a major polar radiometabolite which was identified as 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol and proved the presence of a 3 beta-hydroxysteroid-7 alpha-hydroxylase in prostate. Such evidences may bring new leads for the study of the mechanisms of androgenic steroid action in the prostate gland.
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