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  • Title: Acute saline expansion lowers blood pressure of early DOCA salt hypertensive rats.
    Author: Villamil MF, Amorena C, Ponce J, Müller A, Taquini AC.
    Journal: Pflugers Arch; 1981 Jun; 390(3):260-1. PubMed ID: 7196024.
    Abstract:
    Changes in blood pressure and body fluids volume caused by an acute saline load were studied in 6 normal and 7 DOCA-salt early hypertensive rats having normal inulin space and plasma volume. After loading, blood pressure increased in the normal group (+23 mm Hg) and fell (-17 mm Hg) in the DOCA-salt group. Expansion of extracellular fluid volume was similar in both groups but expansion of plasma volume was twice as high in the DOCA-salt than in the normal group. The results are compatible with an inhibition of a volume-sensitive vasopressor mechanism possibly involving vasopressin.
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