These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibition of platelet aggregation by 1-alkylimidazole derivatives, thromboxane A synthetase inhibitors.
    Author: Kayama N, Sakaguchi K, Kaneko S, Kubota T, Fukuzawa T, Kawamura S, Yoshimoto T, Yamamoto S.
    Journal: Prostaglandins; 1981 Apr; 21(4):543-54. PubMed ID: 7196056.
    Abstract:
    1-Alkylimidazole derivatives of various sidechain lengths with various functional groups at the terminal end of the alkylchain inhibited the synthesis of thromboxane A2 from arachidonic acid by rabbit platelets and the conversion of prostaglandin H2 to thromboxane A2 by the microsomes of rabbit platelets. These enzyme inhibitors were anti-aggregatory as examined with rabbit and human platelet-rich plasma under various experimental conditions.
    [Abstract] [Full Text] [Related] [New Search]