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  • Title: [GABA-ergic correlates of aggression and intraspecies sociability of mice subjected to isolation].
    Author: Poshivalov VP.
    Journal: Biull Eksp Biol Med; 1981 May; 91(5):584-7. PubMed ID: 7196267.
    Abstract:
    Experiments on isolated mice (CC57W males) have demonstrated that GABA antagonists (bicuculline, picrotoxin, thiosemicarbazide) increase the desocializing effects of isolation (enhance aggression and reduce intraspecies sociability), while GABA-positive drugs (muscimol, gamma-acetylenic GABA) within a certain dosage range diminish aggression and favour a temporary recovery of sociability. It is suggested that GABA deficiency in the CNS of isolated mice is a pathogenetic link responsible for the pathological behavior -- superaggression and hyper-reactivity.
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