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  • Title: Isolation and partial characterization of a 67Ga-binding glycoprotein from Morris 5123C rat hepatoma.
    Author: Lawless D, Brown DH, Hübner KF, Colyer SP, Carlton JE, Hayes RL.
    Journal: Cancer Res; 1978 Dec; 38(12):4440-4. PubMed ID: 719629.
    Abstract:
    A Glycoprotein, particularly high in tumors, has been extracted from Morris 5123C rat hepatomas and purified. The compound constitutes a major binding component for 67Ga in this hepatoma. It has a molecular weight of approximately 45,000. Its molecular weight was determined by sodium dodecyl sulfate:polyacrylamide gel electrophoresis and by Sephadex G-200 superfine gel filtration. The steps involved in its extraction and purification include ultrafiltration, gel filtration through Sephadex G-200 superfine, ion-exchange chromatography on diethylaminoethyl Sephadex A-50, and hydroxylapatite chromatography. The homogeneity of the compound was established by gel electrophoresis. The NH2-terminal residue, the percentage of nitrogen, the nonamino carbohydrate content, and the amino acid composition are reported.
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