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  • Title: [Emotionally positive reactions in the process of development of diazepam dependence].
    Author: Zvartau EE.
    Journal: Farmakol Toksikol; 1981; 44(1):21-5. PubMed ID: 7196342.
    Abstract:
    Rats with lateral hypothalamic electrodes were treated with diazepam in doses of 10--20 mg/kd during 10 days. Part of the animals showed tolerance to the inhibitory effect of the drug. Within the drug administration period depression of the self-stimulation response was observed under 24-hour abstinence. After diazepam withdrawal two forms of abstinent changes were noted--inhibition and facilitation. The effects of diazepam were modulated by opiate receptors' blockade with naloxon.
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