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  • Title: Freeze-fracture electronmicroscopic analysis of plasma membranes of cultured muscle cells in Duchenne dystrophy.
    Author: Osame M, Engel AG, Rebouche CJ, Scott RE.
    Journal: Neurology; 1981 Aug; 31(8):972-9. PubMed ID: 7196524.
    Abstract:
    Depletion of intramembranous particles has been reported in the muscle fiber plasma membrane in Duchenne dystrophy. We searched for a similar abnormality in plasma membranes of cultured muscle cells obtained from six patients with Duchenne dystrophy and six controls. A precise method for phase microscopic to freeze-fracture electronmicroscopic correlation was devised to identify the cell of origin of each replicated membrane face. For both control and patient cells, P-face particle density was higher in myotubes than in mononuclear cells. However, there were no significant differences between control and dystrophic cells when comparing P faces of myotubes, E faces of myotubes, P faces of single cells, or E faces of single cells. The frequency distribution of particle diameters was similar in P faces of control and Duchenne myotubes. Other structural features of the freeze-fractured plasma membrane also were similar.
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