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  • Title: [Dynamics of the content of estradiol cytoplasmic and nuclear receptors in the rat hypothalamus in the course of the estrous cycle and postnatal development].
    Author: Peryshkova TA, Shishkina IV, Ozol' LIu, Babichev VN.
    Journal: Ontogenez; 1981; 12(4):390-7. PubMed ID: 7197011.
    Abstract:
    The content of receptors to estradiol in the cytoplasmic and nuclear hypothalamus fractions was studied in female rats during the postnatal development and oestral cycle. In the cytosol of 7 and 14 days old females and in the nuclear fraction of 7 days old females, E2-binding proteins having high capacity were identified as L-fetoprotein. The appearance of true receptors to E2 in the cytosol was shown in the 21 day old females and in the nuclear fraction in the 14 days old ones. In the other age periods until the 35th day, the parallel decrease in the content of both cytoplasmic and nuclear receptors was observed. The binding capacity of the cytoplasmic and nuclear receptors to estradiol in the preoptical area and the arcuate nucleus and median eminence area suffered marked changes with respect to different stages of the oestral cycle, and, within each stage, to day time.
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