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  • Title: Enhanced ratio of linoleic acid to arachidonic acid in erythrocyte phosphatidylcholine in rats during withdrawal from ethanol.
    Author: Rao GA, Goheen SC, Manix M, Larkin EC.
    Journal: Toxicol Lett; 1980 Nov; 7(1):37-40. PubMed ID: 7197409.
    Abstract:
    Male Sprague-Dawley rats were pair-fed for 8 weeks either an alcohol diet or a control diet made isocaloric with dextrose. Those on the alcohol diet were then fed the control diet for 3 days and both groups were killed. Analysis of the fatty acid composition of the various blood lipids showed that the relative level of 18:2 to 20:4 was significantly greater in the phosphatidylcholine fraction from erythrocytes of rats withdrawn from alcohol as compared to that from control animals. It has been suggested that in alcohol-fed animals the hepatic capacity to produce 20:4 from 18:2 is reduced. Therefore the increase in the ratio of 18:2/20:4 in erythrocyte phosphatidylcholine could serve as an index to detect the liver malfunction and to confirm recent chronic alcohol consumption.
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