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  • Title: Plasma MHPG in rapid cyclers and healthy twins.
    Author: Jimerson DC, Nurnberger JI, Post RM, Gershon ES, Kopin IJ.
    Journal: Arch Gen Psychiatry; 1981 Nov; 38(11):1287-90. PubMed ID: 7197905.
    Abstract:
    We measured plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) in 13 pairs of healthy drug-free monozygotic twins. High concordance for both free and conjugated MHPG suggests that plasma levels of the metabolite may reflect a heritable biological trait. In two drug-free rapidly cycling patients studied longitudinally, plasma MHPG levels reflected alterations in psychiatric state; they were significantly higher during mania than during depression. Although largely reflecting peripheral sources, plasma MHPG level as a global index of noradrenergic function may complement urinary MHPG excretion as a probe for diagnostic subgroups or pharmacologic responsiveness in psychiatric research.
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