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  • Title: Enhancement of the antitumor effect of 6-mercaptopurine by vitamin A.
    Author: Akiyama S, Masuda A, Tabuki T, Kuwano M, Komiyama S.
    Journal: Gan; 1981 Oct; 72(5):742-6. PubMed ID: 7199007.
    Abstract:
    The inhibition of the growth of HeLa cells in culture by 6-mercaptopurine was greatly enhanced in combination with retinol, retinal or retinol acetate, but not in combination with retinoic acid or retinol palmitate. The antitumor effect of retinol palmitate combined with 6-mercaptopurine was examined in BDF1 mice with L1210 leukemia. The blood level of retinol, a strong potentiator of 6-mercaptopurine among vitamin A compounds, was increased in BDF1 mice after retinol palmitate injection. Retinol palmitate was found to enhance the antitumor effect of 6-mercaptopurine against murine L1210 leukemia to a significant extent (69% increase in life span).
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