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  • Title: [The effect of midazolam on general hemodynamics and cerebral blood flow in animals and man (author's transl)].
    Author: Hilfiker O, Kettler D.
    Journal: Arzneimittelforschung; 1981; 31(12a):2236-7. PubMed ID: 7199327.
    Abstract:
    8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam Ro 21-3981, Dormicum) has a number of useful properties--including good tolerance on i.v. injection, and short duration of action--which make it a valuable substance in anesthesiology. The present study deals in particular with the general, coronary and cerebral hemodynamics. Observed hemodynamic effects lasted no more than 10 min, which renders midazolam a drug of good controllability.
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