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  • Title: [Studies on the analysis of propafenone by means of internal analogue standardization (author's transl)].
    Author: Brode E, Sachse R, Hoffmann HD.
    Journal: Arzneimittelforschung; 1982; 32(1):1-6. PubMed ID: 7199335.
    Abstract:
    A high-pressure liquid chromatographic method with internal analogue standardization is described for the determination of 2'-(2-hydroxy-3-propylamino-propoxy)-3-phenylpropiophenone hydrochloride (propafenone, Rytmonorm) in plasma. The requirement of selectivity is met: there is no interference of plasma components and propafenone metabolites found in plasma extracts. When using a 2-ml sample the lower limit of detection is approximately 1 ng/ml, the lower limit of determination about 5 ng/ml. In the concentration range up to 250 ng/ml a mean weighted relative error of about 3% has to be expected.
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