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Title: Mutagenicity and chemical analysis of aliphatic and aromatic fractions of Prudhoe Bay crude oil and fuel oil no. 2. Author: Ellenton JA, Hallett DJ. Journal: J Toxicol Environ Health; 1981; 8(5-6):959-72. PubMed ID: 7200152. Abstract: The mutagenicity of aliphatic (fraction 1), one- to three-ring aromatic (fraction 3), and four- to five-ring aromatic (fraction 4) fractions of Prudhoe Bay crude oil and of a fuel oil no. 2 was investigated with a battery of in vitro mammalian and microbial assays. Chemical analysis of the fractions was carried out by gas capillary chromatography-mass spectrometry. In the Salmonella/mammalian microsome test, both first fractions were negative, while fraction 3 of Prudhoe Bay crude and fraction 4 of both oils exhibited mutagenic activity with metabolic activation. In Chinese hamster ovary cells, all of the aromatic fractions, in the presence of metabolic activation, caused a significant increase in the number of sister chromatid exchanges. Chromosome aberrations were not caused by any of the aromatic fractions; however, fraction 3 of fuel oil no. 2 induced endoreduplication in the presence of metabolic activation.[Abstract] [Full Text] [Related] [New Search]