These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of haloperidol and chlorpromazine on reversal learning of normal and striatectomized rats in a Y-maze.
    Author: Arushanian EB, Baturin VA.
    Journal: Pharmacol Biochem Behav; 1982 Apr; 16(4):541-5. PubMed ID: 7200243.
    Abstract:
    Haloperidol (0.05-0.1 mg/kg) and chlorpromazine (0.5-1.0 mg/kg) improved reversal learning avoidance responses in a Y-maze, decreased intersessional fluctuations of errors and decreased the number of spontaneous exits from a correctly selected chamber. After bilateral lesions of the striatum this effect disappeared. Brain lesions also attenuated the ability of neuroleptics to suppress amphetamine-induced stereotypy and and accompanying defects in avoidance responses. The improvement of avoidance behavior by neuroleptics may be related to the reduction of spatial preference caused by functional asymmetry between the bilateral nigro-striatal systems.
    [Abstract] [Full Text] [Related] [New Search]