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  • Title: [Radioimmunoassay for prostatic acid phosphatase in human serum. Methodologic aspects (author's transl)].
    Author: Pradalier N, Canal P, Pujol A, Fregevu Y, Soula G.
    Journal: Ann Biol Clin (Paris); 1982; 40(1):45-50. PubMed ID: 7200750.
    Abstract:
    We propose a double antibody radioimmunoassay for human prostatic acid phosphatase (PAP) in serum for diagnosis and management of prostatic adenocarcinoma under treatment. The antigen is purified from human prostatic fluid by a gel-filtration on Sephadex G 100 followed by affinity chromatography on Con A Sepharose. A specific antibody is raised in rabbits and purified by immunoadsorption with a female serum. The described technique offers both radioisotopic sensibility and immunologic specificity. Physiological values determined in the serum of 125 healthy males are below 2 ng/ml. No significative differences are observed with age. The proposed technique also shows significant differences between values evaluated for benign prostatic hyperplasia and prostatic adenocarcinoma.
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