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  • Title: The effect of calcium, neostigmine and 4-aminopyridine upon respiratory arrest and depression of cardiovascular functions after aminoglycosidic antibiotics.
    Author: Sobek V.
    Journal: Arzneimittelforschung; 1982; 32(3):222-4. PubMed ID: 7200780.
    Abstract:
    Neomycin causes arrest of peripheral respiration by blocking neuromuscular transmission by a presynaptic mechanism. It is not effective in the postsynaptic region until 14fold concentrations are used and it acts by a mechanism different from that of d-tubocurarine. Besides this, it has cardio-depressive effects. The common action of neomycin in all systems apparently concerns the movement of calcium across cell membranes. Calcium and 4-amino-pyridine act as antagonists of the curare-like activities of neomycin and its cardio-depressive action. Neostigmine is not an antagonist of these side-effects. 4-Aminopyridine is effective even in the case of calcium resistance which occurs after combination of several drugs related to neuromuscular transmission and neomycin.
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