These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Induction of sister-chromatid exchanges, cell-cycle delay and chromosomal aberrations by human urine concentrates.
    Author: Beek B, Aranda I, Thomson E.
    Journal: Mutat Res; 1982 Feb 22; 92(1-2):333-60. PubMed ID: 7201069.
    Abstract:
    Human urine concentrates, prepared with the use of XAD-2 resin, are shown to be potent inducers of sister-chromatid exchanges, and especially of chromosomal damage and cell-cycle delay in Chinese hamster ovary cells. No indications for differences in mutagenic activity were found between concentrates prepared from the urine of smokers, non-smokers or patients with alcoholic cirrhosis of the liver. These effects were obtained without metabolic activation in vitro. Experiments including variations in preparative procedures indicate that a quick saturation of the resin by non-polar compounds from human urine may lead to an underestimation of the amount of mutagenic substances in a given urine sample.
    [Abstract] [Full Text] [Related] [New Search]