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  • Title: [Cholesteatoma, oto- and tympanosclerosis: their general mechanism of tissue destruction (author's transl)].
    Author: Mann W, Jonas I, Riede UN, Beck C.
    Journal: Laryngol Rhinol Otol (Stuttg); 1981 Aug; 60(8):426-30. PubMed ID: 7202091.
    Abstract:
    The connective tissue contains extracellular enzymes for the turnover of the ground substance. If this enzyme system gets out of control there is development of a complex metabolic disturbance of all tissue components. The lysosomal dysfunction is the basis of the general mechanism of tissue destruction in cholesteatoma, oto- and tympanosclerosis. This process seems most enhanced in cholesteatoma. Emphasis is placed on the role of extracellular lysosomes (= matrix vesicles).
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