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  • Title: Effect of smoking on the elimination of propranolol hydrochloride.
    Author: Gardner SK, Cady WJ, Ong YS.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1980 Oct; 18(10):421-4. PubMed ID: 7203717.
    Abstract:
    The effect of smoking on the elimination characteristics of propranolol was determined in 20 patients, 10 smokers and 10 non-smokers, who were taking the drug on a continual basis. Smokers took larger doses than non-smokers. The apparent body clearance (ABC) of propranolol in the smoking group was significantly greater than in the non-smoking group (p less than 0.01). When the serum concentrations were adjusted for body weight and dose, the non-smoking group had significantly higher serum concentrations than did the smoking group. The values for half-live (t 1/2) and elimination (k) demonstrated a trend toward a decreases in t 1/2 and increase in k in the group of smokers.
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