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  • Title: The effect of certain variables on the tumor and tissue distribution of tracers. II. Carrier effect: rapidity of onset and concentrations necessary for initiation and maximum response.
    Author: Hagan PL, Halpern SE, Stern P, Dabbs J, Gordon R.
    Journal: Invest Radiol; 1980; 15(6):496-501. PubMed ID: 7203904.
    Abstract:
    The smallest quantity of carrier Ga and Mn necessary to initiate and maximize a carrier effect was studied in the Morris 7777 rat hepatoma model. The quantity needed for a maximum response did not appear to adversely effect the rats. Not all tissues were equally affected at the same plasma concentrations. If carrier Ga was administered 2 hours following 67Ga injection and the rats sacrificed 30 minutes later, a dramatic change occurred in background activity, which was more pronounced in healthy than malignant tissues. Early viable and nonviable tumor/background ratios were improved by this technique. The data suggest that the use of carrier Ga and Mn might improve early lesion/background ratios in patients. This could be of use if tumor imaging were undertaken with 68Ga or 52mMn with positron detector systems.
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