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  • Title: Liver toxicity of ionic (Diatrizoate) and nonionic (C-29) contrast materials: effects of serum enzymes after hepatic artery injection in the rat.
    Author: Måre K, Almén T, Lindell B.
    Journal: Invest Radiol; 1980; 15(6):502-6. PubMed ID: 7203905.
    Abstract:
    Catheters were placed in the retrograde direction in the surgically exposed gastroduodenal arteries of rats. There was an early postoperative mortality of one-third of the animals. The catheter was exteriorized at the tail and was used for arterial perfusion of the liver with one experimental, nonionic contrast medium (C-29) and one ionic contrast medium (diatrizoate). Both contrast media (370 mg I/ml) were injected in a dose of 4 ml/kg rat. The contrast medium injections caused no significant changes in serum levels of the enzymes ALAT, ASAT, or GT.
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