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  • Title: First-pass effect: nonlinear concept comprising an explicit solution of integrated Michaelis-Menten equation.
    Author: Keller F, Scholle J.
    Journal: J Pharm Sci; 1981 Feb; 70(2):195-8. PubMed ID: 7205226.
    Abstract:
    The first-pass effect results from metabolism during the first liver passage of a drug given by mouth. The metabolism is described by the Michaelis-Menten equation, but the integrated form of the Michaelis-Menten equation has no explicit solution for concentration and its handling requires a computer. However, the presented nonlinear equation of the first-pass effect is an explicit integration of the Michaelis-Menten equation and involves only general mathematics. However, the problem of evaluating the Michaelis-Menten constants Vm and Km is not resolved. Therefore, linear equations are also derived, which correspond to previous clearance models.
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