These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of clonazepam on neuronal activity in the sensomotor cortex of rat brain].
    Author: Schmidt I, Eler I, Fisenko VP.
    Journal: Farmakol Toksikol; 1978; 41(6):674-6. PubMed ID: 720578.
    Abstract:
    In tests on flaxedyl immobilized rats the effect of clonazepam on the action produced by gamma-aminobutyric acid, acetylcholine and L-glutamate, delivered microionophoretically to neurons of the sensomotor brain cortex, was investigated. Clonazepam was found to potentiate the inhibiting action of gamma-aminobutyric acid and reduce the exciting effect of acetylcholine and L-glutamate on the spontaneous neuronal activity. The ability of clonazepam, like other tranquilizers of the benzodiazepine series, to augment the sensitivity of the receptive neurons formations to gamma-aminobutyric acid and also influence the ionic permeability of the post-synaptic membrane is suggested.
    [Abstract] [Full Text] [Related] [New Search]