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  • Title: Growth hormone enhances basement membrane thickening in experimental diabetes. A preliminary report.
    Author: Osterby R, Seyer-Hansen K, Gundersen HJ, Lundbaek K.
    Journal: Diabetologia; 1978 Dec; 15(6):487-9. PubMed ID: 720783.
    Abstract:
    Injection of porcine growth hormone (200 microgram) or saline 5 days a week for 16 to 20 weeks in streptozotocin-diabetic rats showed that compared to saline growth hormone produced a 2 1/2-fold larger increase in glomerular capillary basement membrane thickness (2p = 0.027). The possible significance of this effect of an elevated level of growth hormone for diabetic microangiopathy is discussed.
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