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  • Title: [Familial diabetes insipidus of central origin (author's transl)].
    Author: Bruguier A, Poisson D, Lestradet H, Labrune B.
    Journal: Nouv Presse Med; 1981 Mar 07; 10(11):897-9. PubMed ID: 7208293.
    Abstract:
    In a 10-year-old girl admitted to hospital for polyuria and polydipsia, the central nervous system origin of the symptoms was demonstrated by low antidiuretic hormone levels (inferior to 1 pg/ml) and reduction of diuresis after administration of 1-deamino-8D-arginine-vasopressin (DDAVP). A study of the girl's family history showed that the disease was hereditary and autosomal dominant. Intranasal instillations of DDAVP twice daily constitute the best known treatment of the condition.
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