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  • Title: [Erythema nodosum and oral contraception. Demonstration of an anti-ethinyl estradiol antibody].
    Author: Touboul JL, Beaumont V, Meyniel D, Pieron R.
    Journal: Nouv Presse Med; 1981 Feb 28; 10(9):712. PubMed ID: 7208317.
    Abstract:
    The article reports a case of a 23 year old patient on combined oral contraception (OC) for 2 1/2 years, hospitalized for persistent fever. Sural phlebitis and extended erythema nodosum were diagnosed. OC treatment was discontinued and the patient, treated with penicillin and calcium heparinate, left the hospital after 1 week. While thrombotic accidents during OC treatment are well documented, there have been only 13 cases of erythema nodosum. The case presented here is of particular interest because of the association between phlebitis and erythema nodosum, and because the antiethinyl estradiol antibodies found in the patient's serum are those usually found during thrombosis caused by OCs. An immunologic mechanism may be the cause of such an accident.
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