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  • Title: Effect of L-tryptophan on apomorphine-induced growth hormone secretion in normal subjects.
    Author: Lal S, Young SN, Cervantes P, Guyda H.
    Journal: Pharmakopsychiatr Neuropsychopharmakol; 1980 Nov; 13(6):331-5. PubMed ID: 7208604.
    Abstract:
    Oral administration of the serotonin precursor, L-tryptophan, to normal male volunteers (n = 7) in a dose (3 g) sufficient to increase free plasma tryptophan concentrations more than 12-fold had no significant effect on basal growth hormone secretion or on apomorphine HCL-induced (0.75 mg sc) peak growth hormone concentrations. These data suggest that, in man, tryptophan administration has little effect on central dopaminergic function, at least in the hypothalamic-pituitary axis and that serotonergic mechanisms have no major modulatory effect on dopamine-mediated growth hormone secretion.
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