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  • Title: A double-blind, placebo controlled, crossover trial of carbamazepine in overactive, severely mentally handicapped patients.
    Author: Reid AH, Naylor GJ, Kay DS.
    Journal: Psychol Med; 1981 Feb; 11(1):109-13. PubMed ID: 7208734.
    Abstract:
    A double-blind, placebo controlled, crossover trial of carbamazepine in 12 severely and profoundly mentally retarded, overactive adult patients is described. The trial lasted 7 months and those patients in whom overactivity was the dominant problem responded to some degree to carbamazepine with a reduction in overactivity. This was particularly so in patients in whom overactivity was accompanied by some elevation of mood. Patients in whom overactivity was part of a wider spectrum of multiple behaviour disorders showed a scatter of responses. There was no relationship between response to carbamazepine and the presence or absence of epilepsy. The trial identified a small group of mentally retarded patients in whom carbamazepine might be clinically useful.
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