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  • Title: [Arterial plasma histamine concentration during inhalation of allergen and acetylcholine before and after vagotomy. V. Communication (author's transl)].
    Author: Zimmermann I, Ulmer WT.
    Journal: Res Exp Med (Berl); 1980; 178(1):29-35. PubMed ID: 7209132.
    Abstract:
    In allergic dogs ascaris extract (A.E.) inhalation and, to a less extent, acetylcholine inhalation cause a significant increase in the histamine concentration in the arterial plasma. A.E. and acetylcholine cause a similarly strong increase in Edyn. After bilateral vagotomy A.E. and acetylcholine inhalation entail only a minimal increase in Edyn. The increase in the arterial plasma histamine concentration is as strong as before vagotomy. The results support the assumption that both A.E. and acetylcholine act on the sensory receptors of the reflexway via a reflex mechanism. PO2a decreases as Edyn increases. However, after vagotomy PO2a still decreases significantly although Edyn changes hardly. A.E. and acetylcholine are assumed to have a direct effect on the non-vagus controlled peripheral airways. The peripheral airways are mainly responsible for changes in the arterial blood gases but show no effect on Edyn or airway resistance measurements.
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