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  • Title: Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone.
    Author: Sawyer WH, Pang PK, Seto J, McEnroe M, Lammek B, Manning M.
    Journal: Science; 1981 Apr 03; 212(4490):49-51. PubMed ID: 7209515.
    Abstract:
    Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.
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