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  • Title: [Ontogenic differences of glutamate decarboxylase, GABA-aminotransferase, monoamine oxidase activities of cerebral cortex mitochondria and hypothalamic cerebral area].
    Author: Gordienko EA, Zhubrikova LA.
    Journal: Ukr Biokhim Zh (1978); 1980; 52(4):423-8. PubMed ID: 7210203.
    Abstract:
    It is shown that the glutamate decarboxylase activity in the initial mitochondrial fraction of "light" and "heavy" synaptosomes of cerebral hemispheres changes on the 14th, 21st day, 1st, 3d, 12th and 24th months of rat development: in the hypothalamus area it lowers in the initial mitochondria in the 21-day animals, and in the fraction of "heavy" synaptosomes--in the 24 day animals as compared to the adult ones. The GABA-aminotransferase activity in the cortex synaptosome fraction rises in the period between the 14th and 21st day after birthday and in the initial mitochondrial fraction of the hypothalamus area--between the 14th day and the first month of life. In adult rats the glutamate decarboxylase and GABA-aminotransferase activities in the "heavy" synaptosome fraction are higher than in the "light" synaptosome one. The amine oxidase activity of the subcellular fractions which is determined with serotonin as a substrate (form A) is stable during the whole developmental period of studies. The intensity of benzylamine (amine oxidase B) desamination in the cortex fraction and hypothalamus area rises sharply in the second half of ontogenesis.
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