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  • Title: In vitro studies in reproductive immunology. 3. Restoration of mitogenic activity of lymphocytes inhibited by seminal plasma in man.
    Author: Marcus ZH, Hess EV.
    Journal: Arch Androl; 1981 Feb; 6(1):67-74. PubMed ID: 7212851.
    Abstract:
    Human seminal plasma, (HuSePl) is inhibitory to mitogen (PHA-M, Con-A, and PWM) lymphocyte activation. The inhibition does not require the continuous presence of HuSePl. Lymphocyte cultures remain inhibited after 24-hr contact with HuSePl and subsequent washings. Addition of fresh autochthonous lymphocytes or T cells but not B cells can restore the mitogenic activity of HuSePl-inhibited lymphocyte cultures. These observations suggest that T-lymphocyte in the male genital tract are surveilled by HuSePl and lack of inhibitory material could induce an immunologic response by spermatozoal antigens.
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