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  • Title: Progressive systemic sclerosis and nephrotic syndrome. An unusual association resulting in postpartum acute renal failure.
    Author: Palma A, Sanchez-Palencia A, Armas JR, Milan JA, Fernandez-Sanz J, Llach F.
    Journal: Arch Intern Med; 1981 Mar; 141(4):520-1. PubMed ID: 7212897.
    Abstract:
    A 27-year-old, full-term pregnant woman with progressive systemic sclerosis (PSS) came to the hospital with marked proteinuria and edema. Two days later, she gave birth to a normal baby. After delivery and during the next 48 hours, renal failure developed. A renal biopsy specimen disclosed findings characteristic of PSS, and immunofluorescence studies displayed nonspecific deposits of fibrinogen and complement. The patient's general condition deteriorated, with development of pericarditis and pulmonary failure; after several peritoneal dialysis treatments, a peritoneal infection developed, and the patient died of Gram-negative sepsis. The association of PSS and nephrotic syndrome is unusual.
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