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  • Title: Radioimmunoassay for perphenazine in human plasma.
    Author: Midha KK, Mackonka C, Cooper JK, Hubbard JW, Yeung PK.
    Journal: Br J Clin Pharmacol; 1981 Jan; 11(1):85-8. PubMed ID: 7213513.
    Abstract:
    1 A new sensitive, specific and rapid radioimmunoassay procedure for the determination of plasma concentrations of the neuroleptic drug perphenazine is described. 2 The antiserum developed for perphenazine did not cross-react with most of the major metabolites of perphenazine nor the tricyclic antidepressants and antianxiety agents commonly co-administered with the drug. 3 The assay, based on the above antiserum, enabled the quantitation of 50 pg of the drug in 200 microliters of plasma with a coefficient of variation of about 8% and therefore should be applicable for single dose pharmacokinetic studies, as well as therapeutic monitoring of the drug in patients.
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