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  • Title: Ca2+-induced changes in the barrier properties of cardiolipin/phosphatidylcholine bilayers.
    Author: Mandersloot JG, Gerritsen WJ, Leunissen-Bijvelt J, van Echteld CJ, Noordam PC, de Gier J.
    Journal: Biochim Biophys Acta; 1981 Jan 08; 640(1):106-13. PubMed ID: 7213681.
    Abstract:
    (1) A selective increase in permeability is induced in cardiolipin/phosphatidylcholine bilayers at Ca2+ concentrations of 1--3 mM. At higher concentrations of Ca2+ the permeability barrier is completely destroyed. (2) The selective increase in permeability is correlated with the formation of lipid particles visualized by freeze-fracture electron microscopy and an isotropic signal in 31P-NMR spectra. (3) Lowering the Ca2+ concentration shows reduction in permeability but the formation of the lipid particles is a non-reversible process. (4) At higher Ca2+ concentrations, 31P-NMR spectra and freeze-fracture results indicate the formation of the hexagonal phase, explaining the disappearance of the permeability barrier.
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