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  • Title: [Relationship between the effect of bradykinin on microvessels and their initial tonus].
    Author: Khugaeva VK, Suchkov VV, As'muko AA.
    Journal: Biull Eksp Biol Med; 1981; 91(1):3-6. PubMed ID: 7214001.
    Abstract:
    The effect of bradykinin on microcirculation was studied in vivo on the rat mesentery. Bradykinin (0.01--10 micrograms) caused three types of reactions of arterioles and venules (constriction, dilatation, no changes in the diameter) in relation to the dose used. Preliminary application of noradrenaline changed the sensitivity of microvessels to bradykinin towards the increased frequency of dilatation. The increased permeability by red cells in postcapillaries and in venules arose in the areas of the greatest stretch (sites of confluences and ridges of vessels wavy in outline) and was accompanied by deformation and shortening of venules. It was disclosed that bradykinin exerted a pronounced pain effect that promoted awakening of the animals from anesthesia.
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