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  • Title: Neurites from mouse retina and dorsal root ganglion explants show specific behavior within co-cultured tectum or spinal cord.
    Author: Smalheiser NR, Peterson ER, Crain SM.
    Journal: Brain Res; 1981 Mar 16; 208(2):499-505. PubMed ID: 7214158.
    Abstract:
    We have utilized extracellular microiontophoretic injections of horseradish peroxidase into fetal mouse retinal explants to label retinal ganglion cell axons innervating co-cultured tectal explants in a solid Golgi-like manner. Using dorsal root ganglia-tectum and retina-spinal cord co-cultures as controls, our results indicate that retinal neurites show selective growth and arborizations within their appropriate tectal, target tissue. Retinotectal explant co-cultures may be a useful model system for studying aspects of neuronal specificity.
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