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  • Title: Infectivity markers in HBsAg chronic carriers and intrafamilial spread of hepatitis B virus infection.
    Author: Pastore G, Dentico P, Angarano G, Lapedota E, Schiraldi O.
    Journal: Hepatogastroenterology; 1981 Feb; 28(1):20-2. PubMed ID: 7216135.
    Abstract:
    Sera from 28 HBsAg chronic carriers were tested for the presence of HBeAg, anti-HBe and Dane particle-associated DNA-polymerase activity, in order to evaluate the relationship between the presence of these markers and the spread of HBV infection in their family contacts. A highly significant prevalence of HBV infection was observed in the relatives of HBsAg carriers who were positive for either HBeAg or DNA-polymerase activity or both. These observations support the inference of a striking correlation between the presence of these markers and the infectivity of HBsAg carriers. Therefore, serological determination of HBeAg and DNA-polymerase activity may be considered in the epidemiological control of HBV infection
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