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  • Title: Method for antibiotic determination in animal tissue, as applied to lasalocid.
    Author: Mac Donald A.
    Journal: J Assoc Off Anal Chem; 1978 Sep; 61(5):1214-21. PubMed ID: 721734.
    Abstract:
    The development of a tissue residue method for an antibiotic is dependent on the history of the overall problem; the current requirements that must be met for regulatory approval; the chemistry of the compound; its physical/chemical parameters; and its microbiological spectrum for the best possible fit of all of these to ensure a procedure that will work reliably in the originator's laboratory and to the same degree of effectiveness in anyone's laboratory. A note is made of those factors that must be included as controls on the procedure and those experiments that must be included to differentiate matrix from method influences.
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