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  • Title: The in vitro uptake of 14C-praziquantel by cestodes, trematodes, and a nematode.
    Author: Andrews P, Thomas H, Weber H.
    Journal: J Parasitol; 1980 Dec; 66(6):920-5. PubMed ID: 7218112.
    Abstract:
    14C-praziquantel was rapidly taken up by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. Schistosoma mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel throughout the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.
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