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  • Title: A comparison of the anthelmintic effects of oxfendazole and oxibendazole on Trichinella spiralis in mice.
    Author: Karunakaran CS, Denham DA.
    Journal: J Parasitol; 1980 Dec; 66(6):929-32. PubMed ID: 7218114.
    Abstract:
    Oxfendazole was shown to be a very potent agent in killing Trichinella spiralis. A single dose of 1.6 mg/kg per os killed 99% of preadults. Adults were much more resistant; 25 mg/kg killed 56%, even 3,200 mg/kg only killed 94%. Developing and encysted muscle larvae were also killed; 7 X 50 mg/kg killed 99% and 98%, respectively. Oxibendazole was less effective. 6.25 mg/kg killed 99% of preadults, and 3,200 mg/kg killed only 69% of adults. Although oxibendazole also killed developing and encysted muscle larvae, much higher dosages were required; 7 X 200 mg/kg killed 99% of developing larvae and 82% of encysted larvae.
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