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  • Title: Corticosterone binding capacity increases in contralateral hippocampus after partial unilateral hippocampectomy.
    Author: Nyakas C, de Kloet ER, Veldhuis HD, Bohus B.
    Journal: Neurosci Lett; 1981 Feb 06; 21(3):339-43. PubMed ID: 7219881.
    Abstract:
    After unilateral dorsal hippocampectomy the binding of [3H]corticosterone to cytosol receptors in contralateral hippocampus was measured. For estimation of binding capacity the adrenals were removed bilaterally 24 h prior to sacrifice. The apparent maximal binding capacity (Bmax) for corticosterone in the contralateral hippocampus lobe was increased by 74 and 41%, respectively, 10 and 20 days after surgery. The data reveal a novel aspect of steroid receptor capacity control. It is suggested that compensation of altered amounts of receptor sites is an intrinsic property of the hippocampal corticosterone receptor system.
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