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  • Title: Differential susceptibility of Propionibacterium acnes, P. granulosum and P. avidum to free fatty acids.
    Author: Ko HL, Heczko PB, Pulverer G.
    Journal: J Invest Dermatol; 1978 Dec; 71(6):363-5. PubMed ID: 722112.
    Abstract:
    The susceptibility of 98 Propionibacterium acnes, P. granulosum and P. avidum strains isolated from acne cases and appropriate reference strains to decanoic, dodecanoic, octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids was investigated using minimal inhibitory concentration estimation by an agar dilution techique. The tested acids showed their relative antibacterial activity in the following order: C18:3 delta 9,12,15 greater than C18:2 delta 9,12 greater than C12:0 greater than C10:0 Differences between minimal inhibitory concentration values for P. acnes, and P. avidum versus P. granulosum strains were demonstrated in the cases of octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids.
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