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  • Title: [Tienilic acid, hyperuricemia and kidney function].
    Author: de Torrenté A.
    Journal: Schweiz Med Wochenschr; 1981 Mar 14; 111(11):381-5. PubMed ID: 7221513.
    Abstract:
    Tienilic acid (Diflurex) was given to 10 patients with secondary hyperuricemia following hydrochlorothiazide or furosemide administration. Eight of these 10 patients suffered acute worsening of renal function reflected in a significant increase in plasma creatinine. Plasma urates fell in all patients. Plasma creatinine returned to pretreatment levels in all patients within 4 to 15 days. Extreme caution should be exercised in prescribing tienilic acid to hyperuricemic patients, in view of the significant risk of reversible renal impairment.
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