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  • Title: The effect of a high level of dietary leucine on the niacin status of chicks and rats.
    Author: Manson JA, Carpenter KJ.
    Journal: J Nutr; 1978 Dec; 108(12):1883-8. PubMed ID: 722340.
    Abstract:
    Baby chicks were fed purified diets containing 90 g/kg casein and 100 g/kg gelatin. With low levels of niacin and tryptophan, niacin deficiency resulted: this was not exacerbated by the addition of supplementary leucine (17.4 g/kg). With levels of niacin and tryptophan that supported rapid growth the further addition of supplementary leucine depressed food consumption and weight gain; in most instances this was statistically significant. No evidence was obtained to indicate that a high level of dietary leucine could result in niacin deficiency in chicks. Comparable experiments were carried out with weanling rats given a basal diet containing 60 g/kg casein and 60 g/kg gelatin. Adding 15 g/kg L-leucine gave results similar to those obtained with chicks and the same conclusions were drawn.
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